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KMID : 0882420060710010024
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Korean Journal of Medicine
2006 Volume.71 No. 1 p.24 ~ p.37
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Helicobacter pylori cagA, vacA, iceA Gene and Interleukin-1βand Interleukin-1 receptor antagonist gene polymorphisms in gastric carcinoma
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Lee Seong-Hun
Kim Tae-Oh
Kim Gwang-Ha
Lee Dong-Hyun
Park Won-Il
Heo Jeong
Kang Dae-Hwan
Song Geun-Am
Cho Mong
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Abstract
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Background : Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients.
Methods : This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR.
Results : H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma.
Conclusion : Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.
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KEYWORD
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Helicobacter pylori, Interleukin-1, Receptors, Polymorphism, Stomach neoplasms
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